Search results for " Manner"
showing 10 items of 17 documents
A novel microglial subset plays a key role in myelinogenesis in developing brain.
2017
Microglia are resident macrophages of the central nervous system that contribute to homeostasis and neuroinflammation. Although known to play an important role in brain development, their exact function has not been fully described. Here, we show that in contrast to healthy adult and inflammation-activated cells, neonatal microglia show a unique myelinogenic and neurogenic phenotype. A CD11c(+) microglial subset that predominates in primary myelinating areas of the developing brain expresses genes for neuronal and glial survival, migration, and differentiation. These cells are the major source of insulin-like growth factor 1, and its selective depletion from CD11c(+) microglia leads to impa…
Briganti, Longhi und «La Maniera italiana» (1961)
2022
Due inedite testimonianze di Giuliano Briganti e Roberto Longhi gettano luce sul ruolo che lo storico dell'arte assume tanto nella fase di raccolta del materiale iconografico, quanto nella definizione della 'temperatura' del colorito durante la fase di stampa. Il Manierismo, così come si presenta nel volume che Briganti pubblica nel 1961 con Editori Riuniti (Roma) e Verlag der Kunst (Dresden), è un'avanguardia decadentista dal cromatismo inquietante e freddo. Two previously unpublished testimonies by Giuliano Briganti and Roberto Longhi shed light on the role of the art historian in both the collection of iconographic material and the definition of the 'temperature' of colour during the pri…
El management de las conductas socioemocionales. Una aproximación teórica y empírica desde el caso de los agentes de "contact centers"
2020
How is a specific type of emotion-related work conducts formed today? What principles guide these conducts and what effects do they have on those who work? The study of Contact Center agents allows us to understand how a set of personal qualities such as patience and good treatment of others, certain desires and personal impulses or even intimate sensations such as anguish or individual expectations have become managerialized emotions that end up modifying the inner attitudes of these agents. Within this framework, we propose a theoretical approach that integrates the work of Weber, Foucault and Elias, which invites us to reflect on a socio-emotional manner of leading one?s life (Lebensfu?h…
Wealth Creation and Science Research : Science Research, the root of wealth in our Knowledge Society, is endangered
Two vastly dierent historical stages in wealth creation are the traditional one based on agriculture during past millennia, and the one based on science research in our present globalizing knowledge society. The dierences happen to be so considerable, and the emergence of the second stage relatively so recent, that the awareness of the full range of consequences regarding the proper pursuit of science research, which is the root of wealth in our knowledge society, is missing to an extent that may, even in the medium term, seriously endanger the sustainability of modern human society. Here is presented a brief account of some of such dangers, following which a parable, entitled "Is it a mere…
Il Paradigma della Città Fluida
2013
Nella recente crisi globale i poderosi flussi di capitali finanziari, sociali e relazionali che hanno alimentato la riqualificazione urbana nel corso degli ultimi quindici anni non sono più disponibili ad essere intercettati in maniera indiscriminata così come è stato possibile fino a qualche anno fa. Nell'era della crisi strutturale le città più dinamiche non sono più quelle in grado di attrarre progetti urbani iconici ed investitori spinti dal mercato immobiliare o dalla redditività delle attività ricreative, ma quelle città che, a partire dalle loro profonde e diversificate risorse culturali, saranno capaci di attuare una vera e propria “metamorfosi” per usarle come base per la creazione…
Plexin-B1 and Semaphorin 4D Cooperate to Promote Perineural Invasion in a RhoA/ROK-Dependent Manner
2012
Perineural invasion (PNI) is a tropism of tumor cells for nerve bundles located in the surrounding stroma. It is a pathological feature observed in certain tumors, referred to as neurotropic malignancies, that severely limits the ability to establish local control of disease and results in pain, recurrent growth, and distant metastases. Despite the importance of PNI as a prognostic indicator, its biological mechanisms are poorly understood. The semaphorins and their receptors, the plexins, compose a family of proteins originally shown to be important in nerve cell adhesion, axon migration, and proper central nervous system development. Emerging evidence has demonstrated that these factors a…
The law and the risks of stability and integrity for financial institutions
2011
Purpose – There are ever growing relations and mutual influences between law and global economic context: so, there arises the need for them to be investigated in a legal perspective, which is the aim of this paper.Design/methodology/approach – The method used tries to combine the empirical observation of the legal and economic reality in today's world and a few essential theoretical foundations such as the freedom to dispose of one's rights by wave of contractual instrument.Findings – The dramatic crisis that the global world has had to face over the past few years compels legal scholars to revisiting process of traditional categories in order to adapt them to society's changing problems.R…
A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner
2010
Traditional Chinese medicine (TCM) has become very popular in Western countries during the last years. Zicao, a remedy of TCM, has been traditionally used to treat cancer, and, its main constituents, naphthoquinones, have been reported to possess antitumor activity (Chen et al., 2002; Papageorgiou et al., 1999). Here, we prepared extracts of different polarities of Onosma paniculatum Bur.Franch., a plant which is amongst others used as Zicao, but, much less investigated. The extracts were analyzed concerning their growth inhibitory and apoptosis-inducing activity in various tumor cells.Cell viability was measured by XTT viability and a growth inhibition assay. Effects on the cell cycle and …
Madonie, L'arte e la storia
2021
Il volume esamina il patrimonio storico artistico dei seguenti paesi delle Madonie: Caltavuturo, Castelbuono, Cefalù, Collesano, Geraci Siculo, Gangi, Gratteri, Isnello, Petralia Soprana, Petralia Sottana, Polizzi Generosa, Pollina, San Mauro Castelverde e Sclafani Bagni. Per ogni singolo borgo si affronta brevemente la storia della città e successivamente si esaminano le chiese e le opere d’arte ivi contenute, iniziando dalla Chiesa Madre o dalla Basilica per poi continuare con gli altri edifici chiesastici e i palazzi nobiliari. Particolare attenzione viene riservata all’architettura, come le chiese medievali e rinascimentali di Castelbuono, Gratteri e Isnello o quelle barocche e rococò d…
«Un vero e proprio film»: Longhi, Briganti e La Maniera italiana (1961)
2021
Il saggio propone un'analisi dettagliata del percorso editoriale del volume «La Maniera italiana» che Giuliano Briganti pubblica nel 1961 come primo volume di una collana di libri interamente illustrati a colore, redatti da Editori Riuniti insieme a Verlag der Kunst (Dresda, RDT). Grazie a inedite fonti d'archivio questo studio ricostruisce la storia di un singolare episodio di divulgazione storico-artistica che vede Roberto Longhi nella veste di direttore editoriale, affiancato dal critico d'arte Antonio Del Guercio in qualità di segretario redazionale. The essay offers a detailed analysis of Giuliano Briganti's book «La Maniera italiana», which was published in 1961 as the first volume of…